Study finds longer window for stroke treatment
In a Chinese phase 3 study, outcomes improved among patients who received loberamisal within 48 hours.
A randomised study in JAMA reports positive results for loberamisal in certain patients with an acute ischaemic stroke. The researchers stress that further research is needed and that the results do not automatically apply to all patients.
The phase 3 study involved 998 adults treated at 32 Chinese hospitals. They had an acute ischaemic stroke caused by a blocked blood vessel and were eligible to take part within 48 hours of the onset of symptoms. The study examined loberamisal alongside standard care.
Participants were randomly given loberamisal or a placebo. The treatment consisted of daily intravenous administration for ten days. After 90 days, 69.7 per cent of participants in the loberamisal group achieved complete functional recovery according to the prespecified scale. In the placebo group, the figure was 56.3 per cent.
The study reported no clear difference in the total number of adverse events. Serious adverse events occurred in 8.6 per cent of participants who received loberamisal and in 10.7 per cent of those in the placebo group. Such percentages describe the study population and, in themselves, do not indicate what will happen to an individual patient.
The research was conducted as a randomised, double-blind, placebo-controlled trial. This strengthens the reliability of the comparison within the study. At the same time, participants were selected according to age, stroke severity and previous independence. It is therefore not immediately clear whether the results apply to other patient groups or healthcare systems outside China.
The authors write that further studies are needed to confirm the findings and investigate whether the benefit is more broadly applicable. On the basis of this single publication, loberamisal is therefore not a generally available standard treatment. In the event of a stroke, urgent medical assessment remains essential; if sudden symptoms of loss of function occur, it is important to contact the emergency services immediately.
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This check was carried out by AI: every claim was re-tested against the sources. Even an approved article can contain errors — stay critical.
The figures, study design and limitations were checked against the JAMA publication. The text provides no medical advice and explicitly states that further research is needed.
- confirmed The study involved 998 patients at 32 Chinese hospitals. — This is stated in the methods section of the JAMA publication. source
- confirmed After 90 days, 69.7 per cent in the loberamisal group and 56.3 per cent in the placebo group achieved the predefined outcome. — These percentages appear in the study's results. source
- confirmed Further research is needed to confirm the results and establish broader applicability. — The authors themselves state this limitation in the conclusion. source
Editor's note
The study was peer-reviewed and published in JAMA, but the authors call for further research. The results apply to a selected group of participants and do not constitute individual treatment advice.Sources
- Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial — JAMA Network
- Started within 48 hours of stroke, neuroprotective medication helped brain cells, recovery — American Heart Association
More on this in Dutch media
- de Volkskrant — „beroerte loberamisal”
- RTL Nieuws — „beroerte loberamisal”
- NOS — „beroerte loberamisal”